Title : Administration of non - torsadogenic human Ether - à - go - go Related Gene inhibitors is associated with better survival for high hERG - expressing glioblastoma patients

نویسندگان

  • Kelli B. Pointer
  • Paul A. Clark
  • Kevin W. Eliceiri
  • M. Shahriar Salamat
  • Gail A. Robertson
  • John S. Kuo
چکیده

Affiliations: Department of Neurological Surgery, School of Medicine and Public Health; Medical Scientist Training Program, School of Medicine and Public Health; Cellular and Molecular Biology; 4 Laboratory for Optical and Computational Instrumentation (LOCI); 5 Carbone Cancer Center, School of Medicine and Public Health; 6 Department of Pathology and Laboratory Medicine; 7 Departments of Neuroscience, School of Medicine and Public Health; and Cardiovascular Research Center, University of Wisconsin-Madison, Madison WI 9 Department of Surgery, National University of Singapore, Singapore

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Administration of Non-Torsadogenic human Ether-à-go-go-Related Gene Inhibitors Is Associated with Better Survival for High hERG-Expressing Glioblastoma Patients.

PURPOSE Glioblastoma is the most malignant primary brain tumor, with a median survival of less than 2 years. More effective therapeutic approaches are needed to improve clinical outcomes. EXPERIMENTAL DESIGN Glioblastoma patient-derived cells (GPDC) were isolated from patient glioblastomas and implanted in mice to form xenografts. IHC was performed for human Ether-à-go-go-Related Gene (hERG) ...

متن کامل

Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel-Drug Binding Kinetics and Multichannel Pharmacology.

BACKGROUND The current proarrhythmia safety testing paradigm, although highly efficient in preventing new torsadogenic drugs from entering the market, has important limitations that can restrict the development and use of valuable new therapeutics. The CiPA (Comprehensive in vitro Proarrhythmia Assay) proposes to overcome these limitations by evaluating drug effects on multiple cardiac ion chan...

متن کامل

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

Drug-induced block of the cardiac hERG (human Ether-à-go-go-Related Gene) potassium channel delays cardiac repolarization and increases the risk of Torsade de Pointes (TdP), a potentially lethal arrhythmia. A positive hERG assay has been embraced by regulators as a non-clinical predictor of TdP despite a discordance of about 30%. To test whether assaying concomitant block of multiple ion channe...

متن کامل

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

AIMS The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de-Pointes (TdP) arrhythmias. While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold of their hERG inhibitory concentration 50% (IC(50)) values has been suggested, there are drugs tha...

متن کامل

Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel.

hERG (human ether-à-go-go-related gene) potassium (K(+)) channels play a crucial role in electrophysiological activity in the heart, exerting a profound influence on ventricular action potential repolarization and on the duration of the QT interval of the electrocardiogram. hERG channels are strongly implicated in the acquired form of long QT syndrome in that they exhibit a unique susceptibilit...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016